Stem cell factor

Stem cell factor
Stammzellfaktor

Stammzellfaktor

Oberflächenmodell von SCF-Dimer (grün) am Rezeptor-Dimer nach PDB 2E9W
Vorhandene Strukturdaten: 1exz, 1scf, 2e9w
Größe 248 Aminosäuren
Struktur Homodimer
Isoformen 3
Bezeichner
Gen-Namen KITLG; MGF; SCF
Externe IDs OMIM184745 UniProtP21583   MGI96974
Vorkommen
Homologie-Familie Kit ligand
Übergeordnetes Taxon Landwirbeltiere

Der Stammzellfaktor (auch Stem cell factor, SCF, Kit-Ligand oder Steel factor) ist ein Protein aus der Familie der Zytokine, das von entscheidender Bedeutung für das Überleben, die Proliferation und die Differenzierung von Stammzellen, insbesondere Hämatopoietischen Stammzellen und Vorläuferzellen ist. Der Stammzellfaktor existiert in zwei aktiven Formen, einer zellmembrangebundenen und einer freien Variante. Die freie Variante wird aus dem membrangebundenen Stammzellfaktor durch Metalloproteasen gebildet. Seine Effekte vermittelt der Stammzellfaktor durch Aktivierung der Rezeptor-Tyrosinkinase c-Kit.

Weiterführende Literatur

  • Smith M.A., Court E.L., Smith J.G. (2001). Stem cell factor: laboratory and clinical aspects. Blood Rev. 15:191-197.

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