Protein S

Vorhandene Strukturdaten: 1z6c
Größe 635 Aminosäuren; 70,6 kDa
Gen-Namen PROS1; PROS
Externe IDs OMIM176880   MGI1095733
Übergeordnetes Taxon Euteleostomi
Mensch Maus
Entrez 5627 19128
Ensembl ENSG00000184500 ENSMUSG00000022912
UniProt P07225 Q3TR66
Refseq (mRNA) NM_000313 NM_011173
Refseq (Protein) NP_000304 NP_035303
Genlocus Chr 3: 95.07 - 95.18 Mb Chr 16: 62.8 - 62.87 Mb
PubMed Suche [1] [2]

Das Protein S ist ein Vitamin K-abhängiges Plasma-Glykoprotein, das in der Leber gebildet wird. Es wird zur Einleitung der Auflösung eines Blutgerinnsels (Fibrinolyse) benötigt und wirkt als Kofaktor (helfender Faktor) des Protein C.

Ein Protein-S-Mangel führt dementsprechend zu Thrombosen. Protein S wird durch den Faktor C4BP des Komplementsystems reguliert.

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